Pharmaceuticals #genetics#drug approval
Human Genetic Evidence Found to Be Strongly Associated with Drug Approval in Observational Study of 26,278 Target-Disease Pairs
A new observational study analyzing 26,278 target-disease pairs from Open Targets and ChEMBL found that drug targets with human genetic evidence are 3.25 times more likely to receive approval. The enrichment replicated in post-2015 approvals. Feature ablation revealed that literature mining dominates predictive performance, but the classifier has limited practical value. The study catalogs 1,433 genetically supported Phase 1/2 pairs for hypothesis generation.
Jun 16, 2026 1 source